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…showed last 75 words of 399 total…with Manifest Destiny was that anyone that was there or got in the way was dealt with badly. The natives or Indians were not treated fairly or given proper respect. I think that it had the most positive effect on America, because without it, American territory would be as big as the property surrounding its first settlement. Because of the notion of Manifest Destiny, America's drive to explore and conquer new lands will never die.